an inflammatory process driven by LCH cells
          which have underlying neoplastic potential such as aberrant BRAF signaling

     or LCH subtypes are defined by overreaction against unknown triggers
     with an underlying oncogenic potential candidate triggers of overreaction
                         : Merkel cell polyomavirus
                                   cigarette smoking
                                   BCG?

    cf. 1.: Mutation causes a kind of reactive diseas
                                    (familial hemophagocytic lymphohistiocytosis)
    cf. 2.: Overreaction against dermal resident
                                    (an endogenous infection caused by hypersensitivity)
    cf. 3.: MALT lymphoma and H. pylori
    cf. 4.: Langerhans cell sarcoma

              Correspondence:Ichiro Murakami, MD, PhD
                  Department of Pathology, Kochi Medical School of Medicine

  Murakami I. Commentary. J Cranio Max Dis 2013;2:149-50
  LCH Review (PubMed) (Cell Commun Signal)

  Acute-phase ITIH4 levels distinguish multi-system from single
  -system Langerhans cell histiocytosis via plasma peptidomics.

　CHILDREN'S CANCER WEB