准教授
清水 孝洋 Takahiro Shimizu Ph.D.
TEL: 088-880-2326（内線2-2621）
e-Mail: shimizu★kochi-u.ac.jp
所属学会: 日本薬理学会、日本薬学会、日本自律神経学会、北米神経科学会
■ プロフィール
生年月日: 昭和５４年３月１日生
趣味: 野球観戦（北海道生まれの、埼玉西武ライオンズファン）
好きなキャラクター: Woodstock、Snoopy
資格: 医師免許はありませんが、ヤクザ・イシ（薬剤師）の免許を持っています。
性格: 友人には「真面目」「堅物」などと称されますが、昔に比べると丸くなったと思います。
今一番欲しいドラえもんのひみつ道具:
眠くならなくなり、疲れも感じなくなる薬（ひと粒で２４時間有効）
＜ 学歴 ＞
平成９年３月 北海道札幌北高等学校卒業
平成９年４月 北海道大学薬学部総合薬学科入学
平成１３年３月 同 卒業
平成１３年４月 北海道大学大学院薬学研究科修士課程入学
平成１５年３月 同 修了（薬学修士取得）（北海道大学）
平成１６年４月 高知大学大学院医学系研究科博士課程（社会人特別選抜）入学
平成２０年３月 同 修了（医学博士取得）（高知大学）
＜ 職歴 ＞
平成１５年４月 高知医科大学医学部（神経薬理学教室）助手
平成１５年１０月 高知大学医学部（神経薬理学教室）助手
平成１９年４月 高知大学医学部（薬理学講座）助教
平成２３年１０月 高知大学医学部（薬理学講座）講師
平成２４年１２月 高知大学医学部（薬理学講座）准教授
＜ 受賞歴 ＞
平成１７年 第４回KMS Research Meeting優秀発表賞
平成１９年 高知信用金庫・高知安心友の会学術賞
平成２４年 第８５回日本薬理学会年会優秀発表賞
＜ 総説・欧文 ＞
1) Shimizu T, Yokotani K. Roles of the brain phospholipase C, 2-arachidonoylglycerol and arachidonic acid in the central activation of the sympatho-adrenomedullary outflow in rats. The Autonomic Nervous System (Journal of the Japan Society of Neurovegetative Research), 45, 167-177, 2008
＜ 原著・欧文 ＞
1) Okada S, Shimizu T, Yokotani K. Extrahypothalamic corticotropin-releasing hormone mediates (-)-nicotine-induced elevation of plasma corticosterone in rats. Eur. J. Pharmacol., 473, 217-223, 2003
2) Okada S, Shimizu T, Yokotani K. Brain phospholipase C and diacylglycerol lipase are involved in corticotropin-releasing hormone-induced sympatho-adrenomedullary outflow in rats. Eur. J. Pharmacol., 475, 49-54, 2003
3) Shimizu T, Okada S, Yamaguchi-Shima N, Yokotani K. Brain phospholipase C-diacylglycerol lipase pathway is involved in vasopressin-induced release of noradrenaline and adrenaline from adrenal medulla in rats. Eur. J. Pharmacol., 499, 99-105, 2004
4) Shimizu T, Uehara T, Nomura Y. Possible involvement of pyruvate kinase in acquisition of tolerance to hypoxic stress in glial cells. J. Neurochem., 91, 167-175, 2004
5) Nakamura K, Okada S, Yamaguchi N, Shimizu T, Yokotani K, Yokotani K. Role of K+ channels in M2 muscarinic receptor-mediated inhibition of noradrenaline release from the rat stomach. J. Pharmacol. Sci., 96, 286-292, 2004
6) Yokotani K, Okada S, Nakamura K, Yamaguchi-Shima N, Shimizu T, Arai J, Wakiguchi H, Yokotani K. Brain prostanoid TP receptor-mediated adrenal noradrenaline secretion and EP3 receptor-mediated sympathetic noradrenaline release in rats. Eur. J. Pharmacol., 512, 29-35, 2005
7) Shimizu T, Okada S, Yamaguchi N, Arai J, Wakiguchi H, Yokotani K. Brain phospholipase C/diacylglycerol lipase are involved in bombesin BB2 receptor-mediated activation of sympatho-adrenomedullary outflow in rats. Eur. J. Pharmacol., 514, 151-158, 2005
8) Shimizu T, Okada S, Yamaguchi N, Sasaki T, Lu L, Yokotani K. Centrally administered histamine evokes the adrenal secretion of noradrenaline and adrenaline by brain cyclooxygenase-1- and thromboxane A2-mediated mechanisms in rats. Eur. J. Pharmacol., 541, 152-157, 2006
9) Yamaguchi-Shima N, Okada S, Shimizu T, Usui D, Nakamura K, Lu L, Yokotani K. Adrenal adrenaline- and noradrenaline-containing cells and celiac sympathetic ganglia are differentially controlled by centrally administered corticotropin-releasing factor and arginine-vasopressin in rats. Eur. J. Pharmacol., 564, 94-102, 2007
10) Shimizu T, Yamaguchi N, Okada S, Lu L, Sasaki T, Yokotani K. Roles of brain phosphatidylinositol-specific phospholipase C and diacylglycerol lipase in centrally administered histamine-induced adrenomedullary outflow in rats. Eur. J. Pharmacol., 571, 138-144, 2007
11) Yorimitsu M, Okada S, Yamaguchi-Shima N, Shimizu T, Arai J, Yokotani K. Role of brain adrenoceptors in the corticortopin-releasing factor-induced central activation of sympatho-adrenomedullary outflow in rats. Life Sci., 82, 487-494, 2008
12) Shimizu T, Yokotani K. Bidirectional roles of the brain 2-arachidonoyl-sn-glycerol in the centrally administered vasopressin-induced adrenomedullary outflow in rats. Eur. J. Pharmacol., 582, 62-69, 2008
13) Okada S, Yamaguchi-Shima N, Shimizu T, Arai J, Yorimitsu M, Yokotani K. Brain nuclear factor kappa B is involved in the corticotropin-releasing factor-induced central activation of sympatho-adrenomedullary outflow in rats. Eur. J. Pharmacol., 584, 207-212, 2008
14) Okada S, Yamaguchi-Shima N, Shimizu T, Arai J, Yorimitsu M, Yokotani K. Centrally administered N-methyl-D-aspartate evokes the adrenal secretion of noradrenaline and adrenaline by brain thromboxane A2-mediated mechanisms in rats. Eur. J. Pharmacol., 586, 145-150, 2008
15) Okada S, Yamaguchi-Shima N, Shimizu T, Arai J, Lu L, Wakiguchi H, Yokotani K. Role of brain nicotinic acetylcholine receptor in centrally administered corticotropin-releasing factor-induced elevation of plasma corticosterone in rats. Eur. J. Pharmacol., 587, 322-329, 2008
16) Arai J, Okada S, Yamaguchi-Shima N, Shimizu T, Sasaki T, Yorimitsu M, Wakiguchi H, Yokotani K. Role of the brain prostanoids in glucagon-like peptide-1-induced central activation of sympatho-adrenomedullary outflow in rats. Clin. Exp. Phamacol. Physiol., 35, 965-970, 2008
17) Lu L, Shimizu T, Nakamura K, Yokotani K. Brain neuronal/inducible nitric oxide synthases and cyclooxygenase-1 are involved in the bombesin-induced activation of central adrenomedullary outflow in rats. Eur. J. Pharmacol., 590, 177-184, 2008
18) Sasaki T, Shimizu T, Wakiguchi H, Yokotani K. Centrally administered neuromedin U elevates plasma adrenaline by brain prostanoid TP receptor-mediated mechanisms in rats. Eur. J. Pharmacol., 592, 81-86, 2008
19) Usui D, Yamaguchi-Shima N, Okada S, Shimizu T, Wakiguchi H, Yokotani K. Selective activation of the sympathetic ganglia by centrally administered corticotropin-releasing factor in rats. Auton. Neurosci., 146, 111-114, 2009
20) Shimizu T, Yokotani K. Brain cyclooxygenase and prostanoid TP receptors are involved in centrally administered epibatidine-induced secretion of noradrenaline and adrenaline from the adrenal medulla in rats. Eur. J. Pharmacol., 606, 77-83, 2009
21) Usui D, Yamaguchi-Shima N, Okada S, Shimizu T, Wakiguchi H, Yokotani K. Central bombesin activates adrenal adrenaline- and noradrenaline-containing cells via brain thromboxane A2 in rats. Auton. Neurosci., 147, 33-37, 2009
22) Shimizu T, Yokotani K. Effects of centrally administered prostaglandin E3 and thromboxane A3 on plasma noradrenaline and adrenaline in rats: comparison with prostaglandin E2 and thromboxane A2. Eur. J. Pharmacol., 611, 30-34, 2009
23) Shimizu T, Yokotani K. Acute cold exposure-induced down-regulation of CIDEA, cell death-inducing DNA fragmentation factor-a-like effector A, in rat interscapular brown adipose tissue by sympathetically activated β3-adrenoreceptors. Biochem. Biophys. Res. Commun., 387, 294-299, 2009
24) Shimizu T, Lu L, Yokotani K. Possible inhibitory roles of endogenous 2-arachidonoylglycerol during corticotropin-releasing factor-induced activation of central sympatho-adrenomedullary outflow in anesthetized rats. Eur. J. Pharmacol., 641, 54-60, 2010
25) Shimizu T, Tanaka K, Hasegawa T, Yokotani K. Brain a4β2 nicotinic acetylcholine receptors are involved in the secretion of noradrenaline and adrenaline from adrenal medulla in rats. Eur. J. Pharmacol., 654, 241-248, 2011
26) Shimizu T, Lu L, Yokotani K. Endogenously generated 2-arachidonoylglycerol plays an inhibitory role in bombesin-induced activation of central adrenomedullary outflow in rats. Eur. J. Pharmacol., 658, 123-131, 2011
27) Tanaka K, Shimizu T, Lu L, Yokotani K. Possible involvement of S-nitrosylation of brain cyclooxygenase-1 in bombesin-induced central activation of adrenomedullary outflow in rats. Eur. J. Pharmacol., 679, 40-50, 2012
28) Tanaka K, Shimizu T, Lu L, Nakamura K, Yokotani K. Centrally administered bombesin activates COX-containing spinally projecting neurons of the PVN in anesthetized rats. Auton. Neurosci., 169, 63-69, 2012
29) Shimizu T, Tanaka K, Nakamura K, Taniuchi K, Yokotani K. Brain phospholipase C, diacylglycerol lipase and monoacylglycerol lipase are involved in (±)-epibatidine-induced activation of central adrenomedullary outflow in rats. Eur. J. Pharmacol., 691, 93-102, 2012
30) Nakamura K, Shimizu T, Tanaka K, Taniuchi K, Yokotani K. Involvement of presynaptic voltage-dependent Kv3 channel in endothelin-1-induced inhibition of noradrenaline release from rat gastric sympathetic nerves. Eur. J. Pharmacol., 694, 98-103, 2012
31) Shimizu T, Tanaka K, Yokotani K. Stimulatory and inhibitory roles of brain 2-arachidonoylglycerol in bombesin-induced central activation of adrenomedullary outflow in rats. J. Pharmacol. Sci., 121, 157-171, 2013
