原著
Holmström F, Shimizu S, Shimizu T, Higashi Y, Martin DT, Honda M, Saito M.
Protective Effect of Hydroxyfasudil, a Rho Kinase Inhibitor, on Ventral
Prostatic Hyperplasia in the Spontaneously Hypertensive Rat.
Prostate. 2015 Nov;75(15):1774-82. doi: 10.1002/pros.23063. Epub 2015 Aug 19.
[PubMed]
Shimizu S, Shimizu T, Tsounapi P, Higashi Y, Martin DT, Nakamura K, Honda M,
Inoue K, Saito M.Effect of Silodosin, an Alpha1A-Adrenoceptor Antagonist,
on Ventral Prostatic Hyperplasia in the Spontaneously Hypertensive Rat.
PLoS One. 2015 Aug 26;10(8):e0133798. doi: 10.1371/journal.pone.0133798.
eCollection 2015.
[PubMed]
Shimizu T, Tanaka K, Shimizu S, Higashi Y, Yawata T, Nakamura K, Taniuchi K, Ueba T, Yuri K, Saito M. Possible inhibitory role of endogenous 2-arachidonoylglycerol as an endocannabinoid in (±)-epibatidine-induced activation of central adrenomedullary outflow in the rat. Neuropharmacology
2015 Aug;95:278-289. pii: S0028-3908(15)00126-4. doi: 10.1016/j.neuropharm. 2015.03.034.
[PubMed]]
Taniuchi K, Furihata M, Hanazaki K, Iwasaki S, Tanaka K, Shimizu T, Saito M,
Saibara T: Prdx1 promotes pancreatic cancer cell invasion by modulating p38
MAPK activity. Pancreas 2015 Mar;44(2) :331-40.doi:10.1097/MPA.0000000000000270.[PubMed]
総説
総説・和文
清水 孝洋, 齊藤 源顕:ヘモグロビン由来ペプチド・ヘモプレッシンによる交感神経―副腎髄質系賦活に対する中枢性制御:自律神経 52(1):60-64, 2015
東 洋一郎, 中村 久美子, 清水 孝洋, 齊藤 源顕:アンジオテンシンIIの脳内AT1受容体を介したアドレナリン分泌機構ならびに昇圧反
応機構:Angiotensin Research 12(3): 176-179, 2015
清水 翔吾, 清水 孝洋, 東 洋一郎, 齊藤 源顕: 骨盤内血流を標的とした下部尿路症状に対するニコランジルの効果: 日薬理誌 (Folia Pharmacol. Jpn.) 146:21-26, 2015
その他
Kadekawa K, Yoshiyama M, Majima T, Wada N, Shimizu T, Tyagi P, Sugaya K,
Yoshimura N. CHARACTERIZATION OF BLADDER AND EXTERNAL URETHRAL SPHINCTER
ACTIVITY IN MICE WITH OR WITHOUT SPINAL CORD INJURY- A COMPARISON STUDY WITH
RATS. Neurourol Urodyn. 34 (S3):S85-S86, 2015
Kawamoto B, Shimizu S, Hikita K, Muraoka K, Honda M, Sejima T, Higashi Y,
Shimizu T, Takenaka A, Saito M. VESICOVASCULAR REFLEX IN THE SPONTANEOUSLY
HYPERTENSIVE RAT. Neurourol Urodyn. 34 (S3):S89-S90, 2015
Shimizu T, Shimizu S, Higashi Y, Nakamura K, Kadekawa K, Wada N, Majima T,
Honda M, Yoshimura N, Saito M. BOMBESIN, A STRESS-RELATED NEUROPEPTIDE,
CENTRALLY INDUCES FREQUENT URINATION IN THE RAT. Neurourol Urodyn. 34
(S3):S94-S96, 2015
Kawamoto B, Shimizu S, Hikita K, Muraoka K, Honda M, Sejima T, Higashi Y,
Shimizu T, Saito M, Takenaka A. CENTRAL ANGIOTENSIN II INCREASES URINARY
FREQUENCY BY ACTING ON BRAIN AT1 RECEPTORS IN RATS. Neurourol Urodyn. 34
(S3):S102-S103, 2015
Wada N, Kadekawa K, Majima T, Shimizu T, Okada H, Tyagi P, Kakizaki H,
Yoshimura N. URODYNAMIC EFFECT OF INTRAVESICAL AND INTRATHECAL
ADMINISTRATION OF SELECTIVE E-SERIES PROSTAGLANDIN 4 RECEPTOR ANTAGONIST,
ONO-AE3-208, ON CYCLOPHOSPHAMIDE INDUCED CYSTITIS RATS. Neurourol Urodyn. 34
(S3):S134-S135, 2015
Honda M, Kawamoto B, Tsounapi P, Hikita K, Muraoka K, Shimizu S, Saito M,
Sejima T, Takenaka A. PREDICTION OF URINARY INCONTINENCE AFTER
ROBOT-ASSISTED RADICAL PROSTATECTOMY. Neurourol Urodyn. 34
(S3):S151-S152, 2015
Majima T, Tyagi P, Dogishi K, Kadekawa K, Kashyap M, Wada N, Takai S,
Shimizu T, Gotoh M, Chancellor M, Yoshimura N. THE EFFECT OF INTRAVESICAL
LIPOSOME-BASED NGF ANTISENSE THERAPY ON BLADDER OVERACTIVITY AND NOCICEPTION
IN A RAT MODEL OF CYSTITIS INDUCED BY HYDROGEN PEROXIDE. Neurourol Urody. 34
(S3):S201-S203, 2015
Wada N, Kadekawa K, Majima T, Shimizu T, Tyagi P, Kakizaki H, Yoshimura N.
URODYNAMIC EFFECTS OF INTRAVENOUS AND INTRATHECAL ADMINISTRATION OF E-SERIES
PROSTAGLANDIN 1 RECEPTOR ANTAGONIST ON DETRUSOR OVERACTIVITY IN RATS WITH
SPINAL CORD INJURY. Neurourol Urodyn. 34 (S3):S296-S298, 2015
Shimizu S, Martin D, Trejo J, Wheeler M, Liu J, Saito M, Weiss R, Hittelman
A. THE INTRAVESICAL DELIVERY OF BOTULINUM TOXIN A/DIMETHYL SULFOXIDE IN A
NORMAL RAT AND IN AN ACETIC ACID INDUCED BLADDER INFLAMMATORY MODEL.
Neurourol Urodyn. 34 (S3):S334-S336, 2015
Hikita K, Honda M, Kawamoto B, Panagiota T, Muraoka K, Shimizu S, Saito M,
Sejima T, Takenaka A. ADHERENCE TO ANTICHOLINERGIC AGENTS BY JAPANESE FEMALE
OAB PATIENTS: PATIENTS OF OAB WET AND OAB DRY. Neurourol Urodyn. 34
(S3):S409-S410, 2015
Saito M, Shimizu S. Editorial comment to Propiverine increases urethral wall
catecholamine levels and bladder leak point pressure in rats. Int J Urol. 2015 Oct 25. doi: 10.1111/iju.13000. [PubMed]] No
abstract available.
Tsounapi P, Honda M, Dimitriadis F, Shimizu S, Iguchi M, Imanishi M, Matsunaga S,
Kawamoto B, Hikita K, Muraoka K, Sejima T, Sofikitis N, Saito M, Tomita S,
Takenaka A: Unilateral cryptorchidism induces testicular cells' DNA oxidative damage and
apoptosis bilaterally in the rat; the effects of antioxidants administration. Eur Urol Suppl 14(2): e176, 2015
Honda M, Kawamoto B, Morizane K, Hikita K, Muraoka K, Panagiota T, Shimizu S,
Saito M, Sejima T, Takenaka A: A novel risk classification tool to estimate urinary
incontinence after robotic-assisted radical prostatectomy. Eur Urol Suppl 14(2): e358, 2015
Honda M, Yoshimura N, Kawamoto B, Hikita K, Muraoka K, Panagiota T, Shimizu S,
Saito M, Sejima T, Chancellor MB, Takenaka A: The urodynamic effects of intravesical
administration of sensory neuron-specific receptor agonist on cyclophosphamide-induced bladder overactivity in rats. Eur Urol Suppl 14(2): e1089, 2015
Abstract
Saito M, Dimitriadis F, Nikolaos S. The effect of PDE5 inhibitors on
testicular dysfunction inoligoasthenospermic and azoospermic men. J
Pharmacol Sci 128: S49, 2015
Shimizu S, Tsounapi P, Shimizu T, Higashi Y, Nakamura K, Holmstrom F, Saito
M: Selective a1A-adrenoceptor blocker silodosin decreases the prostatic
growth in the spontaneously hypertensive rat. J Pharmacol Sci. 128:S105,
2015
Nakamura K, Shimizu T, Shimizu S, Holmstrom F, Higashi Y, Yawata T, Saito M:
Bombesin centrally induces frequent urination in the rat. J Pharmacol Sci.
128:S239, 2015
Shimizu T, Shimizu S, Nakamura K, Honda M, Inoue K, Saito M: Hydrogen
sulfide is a potent relaxing factor in the rat bladder and prostate. J Urol
193: e232, 2015
Shimizu S, Tsounapi P, Shimizu T, Higashi Y, Nakamura K, Holmstrom F, Honda
M, Inoue K, Saito M: Selectiveα1A-adrenoceptor blocker silodosin ameliorates
ventral prostatic enlargement in the spontaneously hypertensive rat:
possible role of the prostatic blood flow. J Urol 193: e355-e356, 2015
Tsounapi P, Dimitriadis F, Honda M, Shimizu S, Iguchi M, Imanishi M,
Matsunaga S, Kawamoto B, Hikita K, Muraoka Y, Sejima T. Saito M, Sofikitis
N, Tomita S, Takenaka A: The diabetes mellitus-induced dysfunction on
seminal vesicles and vas deferens in the rat model. J Urol 193: e769, 2015
Tsounapi P, Honda M, Dimitriadis F, Shimizu S, Iguchi M, Imanishi M,
Matsunaga S, Kawamoto B, Hikita K, Muraoka Y, Sejima T. Saito M, Sofikitis
N, Tomita S, Takenaka A: Antioxidants administration managed to rescue
testicular cells' oxidative damage and apoptosis bilaterally, in the
unilaterally cryptorchidized rat model. J Urol 193: e986, 2015
国際学会 等
■ ISTERH2015, 会期. 10.18-22, 2015. 於:Sheraton Dubrovnik Riviera Hotel ,Dubrovnik , Croatia
Higashi Y, Saito M: The role of brain zinc in microglial activation.
■ ICS 2015, 会期. 10.6-9, 2015. 於: Palais des Congrès, Montreal, Canada
Kadekawa K, Yoshiyama M, Majima T, Wada N, Shimizu T, Tyagi P, Sugaya K, Yoshimura N: CHARACTERIZATION OF BLADDER AND EXTERNAL URETHRAL SPHINCTER ACTIVITY IN MICE WITH OR WITHOUT SPINAL CORD INJURY- A COMPARISON STUDY WITH RATS
Kawamoto B, Shimizu S, Hikita K, Muraoka K, Honda M, Sejima T, Higashi Y, Shimizu T, Takenaka A, Saito M: VESICOVASCULAR REFLEX IN THE SPONTANEOUSLY HYPERTENSIVE RAT
Shimizu T, Shimizu S, Higashi Y, Nakamura K, Kadekawa K, Wada N, Majima T, Honda M, Yoshimura N, Saito M: BOMBESIN, A STRESS-RELATED NEUROPEPTIDE, CENTRALLY INDUCES FREQUENT URINATION IN THE RAT
Kawamoto B, Shimizu S, Hikita K, Muraoka K, Honda M, Sejima T, Higashi Y, Shimizu T, Saito M, Takenaka A: CENTRAL ANGIOTENSIN II INCREASES URINARY FREQUENCY BY ACTING ON BRAIN AT1 RECEPTORS IN RATS
Wada N, Kadekawa K, Majima T, Shimizu T, Okada H, Tyagi P, Kakizaki H, Yoshimura N: URODYNAMIC EFFECT OF INTRAVESICAL AND INTRATHECAL ADMINISTRATION OF SELECTIVE E-SERIES PROSTAGLANDIN 4 RECEPTOR ANTAGONIST, ONO-AE3-208, ON CYCLOPHOSPHAMIDE INDUCED CYSTITIS RATS
Honda M, Kawamoto B, Tsounapi P, Hikita K, Muraoka K, Shimizu S, Satio M, Sejima T, Takenaka A: PREDICTION OF URINARY INCONTINENCE AFTER ROBOT-ASSISTED RADICAL PROSTATECTOMY
Majima T, Tyagi P, Dogishi K, Kadekawa K, Kashyap M, Wada N, Takai S, Shimizu T, Gotoh M, Chancellor M, Yoshimura N: THE EFFECT OF INTRAVESICAL LIPOSOME-BASED NGF ANTISENSE THERAPY ON BLADDER OVERACTIVITY AND NOCICEPTION IN A RAT MODEL OF CYSTITIS INDUCED BY HYDROGEN PEROXIDE
Wada N, Kadekawa K, Majima T, Shimizu T, Tyagi P, Kakizaki H, Yoshimura N: URODYNAMIC EFFECTS OF INTRAVENOUS AND INTRATHECAL ADMINISTRATION OF E-SERIES PROSTAGLANDIN 1 RECEPTOR ANTAGONIST ON DETRUSOR OVERACTIVITY IN RATS WITH SPINAL CORD INJURY
Shimizu S, Martin D, Trejo J, Wheeler M, Liu J, Saito M, Weiss R, Hittelman A: INTRAVESICAL DELIVERY OF BOTULINUM TOXIN A/DIMETHYL SULFOXIDE IN A NORMAL RAT AND IN AN ACETIC ACID INDUCED BLADDER INFLAMMATORY MODEL
Hikita K, Honda M, Kawamoto B, Panagiota T, Muraoka K, Shimizu S, Saito M, Sejima T, Takenaka A: ADHERENCE TO ANTICHOLINERGIC AGENTS BY JAPANESE FEMALE OAB PATIENTS: PATIENTS OF OAB WET AND OAB DRY
Shimizu S, Shimizu T, Tsounapi P, Higashi Y, Kawamoto B, Hikita K, Muraoka K, Honda M, Inoue K, Saito M: EFFECT OF A SELECTIVE ALPHA1A-ADRENOCEPTOR ANTAGONIST SILODOSIN ON PROSTATIC BLOOD FLOW AND PROSTATIC GROWTH IN THE SPONTANEOUSLY HYPERTENSIVE RAT
Shimizu S, Holmström F, Shimizu T, Higashi Y, Saito M: FASUDIL，A RHO KINASE INHIBITOR, AMELIORATES HYPERPLASIA IN The SPONTANEOUSLY HYPERTENSIVE RAT PROSTATE
■The 10th Pan-Pacific Continence Society Meeting 会期.9.7-8,2015. 於: Sapporo Convention Center (Sapporo, Japan)
Shimizu T, Shimizu S, Nakamura K, Honda M, Inoue K, Yoshimura N,
Saito M: Endogenous hydrogen sulfide can function as a potent relaxing factor in the rat bladder and prostate.
■American Urological Association, 110th Annual Meeting, 会期: 5.15-19,2015.於:New Orleans Morial Convention Center（New Orleans, LA,USA）
Shimizu T, Shimizu S, Nakamura K, Honda M, Inoue K, Saito M: Hydrogen
sulfide is a potent relaxing factor in the rat bladder and prostate
Shimizu S, Tsounapi P, Shimizu T, Higashi Y, Nakamura K, Holmstrom F, Honda
M, Inoue K, Saito M: Selective α1A-adrenoceptor blocker silodosin
ameliorates ventral prostatic enlargement in the spontaneously hypertensive
rat : possible role of the prostatic blood flow
Tsounapi P, Honda M, Dimitriadis F, Shimizu S, Iguchi M, Imanishi M,
Matsunaga S, Kawamoto B, Hikita K, Muraoka K, Sejima T, Saito M, Sofikitis
N, Tomita S, Takenaka A: Antioxidants administration managed to rescue
testicular cells’ DNA oxidative damage and apoptosis bilaterally, in the
unilaterally cryptorchidized rat model
Tsounapi P, Honda M, Dimitriadis F, Shimizu S, Iguchi M, Imanishi M,
Matsunaga S, Kawamoto B, Hikita K, Muraoka K, Sejima T, Saito M, Sofikitis
N, Tomita S, Takenaka A: The Diabetes Mellitus-induced dysfunction on
Seminal Vesicles and Vas Deferens in the rat model
■30th Annual European Association of Urology (EAU) Congress, 会期: 3.20-24,2015.於: IFEMA - Feria de Madrid (Madrid, Spain)
Tsounapi P, Honda M, Dimitriadis F, Shimizu S, Iguchi M, Imanishi M,
Matsunaga S, Kawamoto B, Hikita K, Muraoka K, Sejima T, Sofikitis N,
Saito M, Tomita S, Takenaka A: Unilateral cryptorchidism induces testicular cells' DNA oxidative damage
and apoptosis bilaterally in the rat; the effects of antioxidants administration
Honda M, Kawamoto B, Morizane K, Hikita K, Muraoka K, Panagiota T,
Shimizu S, Saito M, Sejima T, Takenaka A: A novel risk classification tool to estimate urinary
incontinence after robotic-assisted radical prostatectomy
Honda M, Yoshimura N, Kawamoto B, Hikita K, Muraoka K, Panagiota T,
Shimizu S, Saito M, Sejima T, Chancellor MB, Takenaka A: The urodynamic effects of intravesical
administration of sensory neuron-specific receptor agonist on cyclophosphamide-induced bladder overactivity in rats
国内学会 等
■第8回排尿障害モデル動物研究会 会期: 12.4 於:グランディエールブケトーカイ（静岡)
清水翔吾, 清水孝洋, 東洋一郎, 齊藤源顕 : Rho kinase阻害薬ファスジルによる自然発症高血圧ラット前立腺過形成の抑制効果
■第68回日本薬理学会西南部会 会期: 11.21 於: 海峡メッセ下関 (山口)
清水翔吾, 川本文弥, 清水孝洋, 東洋一郎, 中村久美子, 新武享朗, 齊藤源顕: 脳内アンジオテンシンIIは中枢性AT1受容体を介して排尿反射を惹起する
東洋一郎, 新武享朗, 清水翔吾, 清水孝洋, 中村久美子, 齊藤源顕: 脳虚血後のミクログリアを介した炎症反応に対するキレータブル亜鉛の効果についての解析
中村久美子, 清水孝洋,清水翔吾,東洋一郎,齊藤源顕: 硫化水素によるラット膀胱および前立腺に対する弛緩作用と硫化水素産生酵素の発現分布
新武享朗, 東洋一郎, 清水翔吾,清水孝洋,中村久美子,齊藤源顕: 酪酸ナトリウムは脳振とう誘導性うつ病様行動を改善する
■第67回西日本泌尿器科学会総会 会期: 11.5-7 於: 福岡国際会議場 (福岡)
Bunya Kawamoto, Shogo Shimizu, Takahiro Shimizu, Youichirou Higashi,
Katsuya Hikita, Kuniyasu Muraoka, Masashi Honda, Takehiro Sejima, Motoaki
Saito, Atsushi Takenaka: Central Angiotensin II Induces Frequent Urination
in Rats.
■第80回日本泌尿器科学会東部総会 会期: 9.25-27 於: 京王プラザホテル (東京)
川本文弥, 清水翔吾, 清水孝洋, 東洋一郎, 引田克弥, 村岡邦康, 本田正史, 瀬島健裕, 武中篤, 齊藤源顕:
中枢性アンジオテンシンIIが排尿反射に及ぼす影響
■第14回瀬戸内国際臨床試験カンファレンス 会期: 9.27 於: ひめぎんホール (松山)
齊藤源顕: 骨盤内血流と過活動膀胱
■Nagoya Shinshu Forum 2015 会期9.11-12 於：京王プラザ札幌
Shogo Shimizu, Motoaki Saito, Darryl T. Martin, Marcia A Wheeler, Robert M Weiss, Adam B Hittelman: The intravesical delivery of Botulinum toxin A/dimethyl sulfoxide in rat normal and inflammatory bladders
■第22回排尿機能学会 会期: 9.9-11 於: 京王プラザホテル札幌 (札幌)
清水翔吾: 前立腺虚血と前立腺過形成
清水孝洋, 清水翔吾, 齊藤 源顕: ストレス関連ペプチドのボンベシンは中枢性に頻尿を誘発する
清水孝洋, 清水翔吾, 中村久美子, 本田正史, 井上啓史, 齊藤源顕：硫化水素は膀胱ならびに前立腺における強力な弛緩因子である
川本文弥, 清水翔吾, 清水孝洋, 東洋一郎, 引田克弥, 村岡邦康, 本田正史, 瀬島健裕, 武中篤, 齊藤源顕： 脳室内アンジオテンシンIIは中枢性AT1受容体を介して頻尿を惹起する
清水翔吾, Holmstrom Felix, 清水孝洋, 東洋一郎, 中村久美子, 川本文弥, 引田克弥, 村岡邦康, 本田正史, 齊藤源顕：Rho kinase阻害薬ファスジルによる前立腺過形成の抑制効果
村岡邦康, 本田正史, 川本文弥, 清水翔吾, ツナピ パナイオタ, 引田克弥, 齊藤源顕, 瀬島健裕, 武中篤：低活動膀胱に対するHoLEPの効果について
引田克弥, 本田正史, 川本文弥, ツナピ パナイオタ, 村岡邦康, 清水翔吾, 齊藤源顕, 瀬島健裕, 武中篤：女性OAB患者における抗コリン剤の内朊継続率についての検討
■第8回トランスポーター研究会九州部会 会期: 7.18 於:鹿児島大学医学部鶴陵会館（鹿児島）
清水翔吾, 清水孝洋, 東洋一郎, 齊藤源顕: 精巣捻転症の予防と治療法の開発
■第103回日本泌尿器学会総会 会期: 4.18-21 於:石川県立音楽堂他（金沢）
Shogo Shimizu, Panagiota Tsounapi, Takahiro Shimizu, Youichiro Higashi,
Bunya Kawamoto, Naoto Kobayashi, Katsuya Hikita, Kuniyasu Muraoka, Masashi
Honda, Keiji Inoue, Motoaki Saito: The effect of selective α1A-adrenoceptor
blocker silodosin on the prostatic enlargement in the spontaneously
hypertensive rat
川本文弥, 本田正史, 平野慎二, Panagiota Tsounapi, 森實修一, 引田克弥, 村岡邦康, 八尾昭久, 清水翔吾, 齊藤源顕,
瀬島健裕, 武中篤：ロボット支援前立腺全的術後の性機能推移に下部尿路症状が与える影響
本田正史, 川本文弥, 平野慎二, Panagiota Tsounapi, 清水翔吾, 森實修一, 引田克弥, 村岡邦康, 齊藤源顕,
瀬島健裕, 武中篤：陰茎リハビリテーションがロボット支援前立腺全摘除術後下部尿路症状に与える影響
村岡邦康, 本田正史, 平野慎二, 川本文弥, 清水翔吾, Panagiota Tsounapi, 森實修一, 引田克弥, 八尾昭久, 齊藤源顕, 瀬島健裕,
武中篤：排尿筋収縮力からみたHoLEP術後の排尿状態の変化について
引田克弥, 本田正史, 川本文弥, 平野慎二, Panagiota Tsounapi, 村岡邦康, 瀬島健裕, 武中篤, 清水翔吾,
齊藤源顕：前立腺肥大症患者におけるIntravesical prostatic protrusion (IPP)の影響
■第88回 日本薬理学会年会 会期 会期: 3.18-20,2015 於:吊古屋国際会議場（吊古屋）
Motoaki Saito,Fotios Dimitriadis,Sofikitis Nikolaos: The effect of PDE5 inhibitors on testicular dysfunction in oligoasthenospermic and azoospermic men
Shogo Shimizu, Panagiota Tsounapi, Takahiro Shimizu, Youichirou Higashi, Kumiko Nakamura, Felix Holmstrom, Motoaki Saito: Selective α1A-adrenoceptor blocker silodosin decreases the prostatic growth in the spontaneously hypertensive rat
Kumiko Nakamura, Takahiro Shimizu, Shogo Shimizu, Felix Holmstrom, Youichirou Higashi, Toshio Yawata, Motoaki Saito: Bombesin centrally induces frequent urination in the rat