原著
Sekido N, Omae K, Kubota Y, Mitsui T, Masumori N, Haga N, Saito M, Sakakibara R, Yoshida M, Takahashi S. Underactive bladder as defined by the International Continence Society in the 2023 Japan Community Health Survey. Int J Urol. 2025 Jan. doi: 10.1111/iju.15595. PMID: 39382059.Sekido N, Haga N, Omae K, Kubota Y, Mitsui T, Masumori N, Saito M, Sakakibara R, Yoshida M, Takahashi S. Is seated voiding associated with lower urinary tract symptoms, health conditions, or marital status? Finding by age group from the 2023 Japan Community Health Survey. Int J Urol. 2025 Feb. doi: 10.1111/iju.15624. PMID: 39451098.
Haga N, Yoshida M, Mitsui T, Sekido N, Masumori N, Omae K, Saito M, Kubota Y, Sakakibara R, Takahashi S. Prevalence and risk factors of stress urinary incontinence in a 2023 Japanese community health survey - differences between males females. BJUI Compass. 2025;6:e70004. doi: 10.1002/bco2.70004. PMID: 39963579.
Sekido N, Omae K, Haga N, Kubota Y, Saito M, Sakakibara R, Yoshida M, Mitsui T, Masumori N, Takahashi S. Hesitancy or straining, that is the question: Which does question 6 of the International Prostate Symptom Score represent? Int J Urol. 2025, doi: 10.1111/iju.70133. PMID: 40459121.
Sekido N, Omae K, Haga N, Kubota Y, Saito M, Sakakibara R, Yoshida M, Mitsui T, Masumori N, Takahashi S. Prevalence, impact on quality of life, and predictive factors of co-existent overactive-underactive bladder in women. Int J Urol. 2025, doi: 10.1111/iju.70120. PMID: 40406859.
Shimizu T, Shimizu N, Tsubouchi S, Togo M, Higashi Y, Saito M. Centrally administered prostaglandin E2 suppresses the micturition reflex in rats. J Pharmacol Sci. 2025;158:231-237. doi: 10.1016/j.jphs.2025.05.005. PMID: 40436485.
Karashima T, Komatsu T, Yamamoto S, Atagi K, Hashida H, Fukuhara H, Tamura K, Ashida S, Shuin T, Udaka K, Shimizu T, Saito M, Shimizu N, Inoue K. Transcutaneous imiquimod combined with anti-programmed cell death-1 monoclonal antibody extends the survival of mice bearing renal cell carcinoma. Cancer Med. 2025;14:e70966. doi: 10.1002/cam4.70966. PMID: 40371846
Sekido N, Omae K, Haga N, Kubota Y, Saito M, Sakakibara R, Yoshida M, Mitsui T, Masumori N, Takahashi S. Prevalence, impact on quality of life, and predictive factors of coexistence of overactive bladder and underactive bladder in men. Sci Rep. 2025;15(1):21313. doi: 10.1038/s41598-025-06299-w. PMID: 40596098
Omae K, Sekido N, Haga N, Kubota Y, Saito M, Sakakibara R, Yoshida M, Mitsui T, Masumori N, Takahashi S. Unsupervised machine learning approach to interpret complex lower urinary tract symptoms and their impact on quality of life in adult women. World J Urol. 2025;43:474. doi: 10.1007/s00345-025-05849-1. PMID: 40760055
Shimizu N, Shimizu T, Togo M, Higashi Y, Fukata S, Inoue K, Saito M. Potential role of brain nitric oxide in inhibiting alpha7 nicotinic acetylcholine receptor-mediated suppression of the micturition reflex in rats. Nitric Oxide 2025;158:116-123. doi: 10.1016/j.niox.2025.07.003. PMID: 40720991
Morishita Y, Higashi Y, Tani D, Togo M, Shimizu T, Fujieda M, Saito M. Subacute intranasal oxytocin improves neurological recovery after ischemic stroke. J Pharmacol Sci 2025;159:151-158. doi: 10.1016/j.jphs.2025.08.006.
Nakamura R, Okada M, Takahashi A, Hayashi Y, Konishi M, Murakami I, Saito M, Akizawa T. A synthetic nonapeptide, JAL-TA9, inhibits neuronal cytotoxicity caused by Aβ25-35 aggregation with proteolytic activity. Neurobiology of Aging. 2025 Sep. doi: 10.1016/j.neurobiolaging.2025.09.001. PMID: 40925093
症例報告・英文
Yoshimura R, Shimizu N, Togo M, Yamamoto S, Nao T, Shimamoto T, Fukuhara H, Fukata S, Ashida S, Karashima T, Saito M, Inoue K. Cough-associated detrusor overactivity resolved after intravesical onabotulinumtoxin A injection: A case report. Urology Case Reports 2025;62:103129. doi: 10.1016/j.eucr.2025.103129. PMID: 40727544
総説・和文
総説・英文
著書
その他
Shimizu N, Shimizu T, Inoue K, Saito M. Brain nitric oxide inhibits the brain α7 nicotinic acetylcholine receptor-mediated suppression of the rat micturition reflex. J Urol. 2025. 213(5S), e281.
Shimizu T, Shimizu N, Tsubouchi S, Togo M, Higashi Y, Saito M. Centrally administered prostaglandin E2 suppresses the rat micturition reflex via brain EP1 and EP2 receptor. Continence 2025 15S: 102260. doi.org/10.1016/j.cont.2025.102260
Shimizu T, Takeuchi Y, Higashi Y, Shimizu N, Saito M. Centrally administered histamine facilitates the micturition reflex via brain H1 and H2 receptors in rats. Continence 2025 15S: 102257. doi.org/10.1016/j.cont.2025.102257
Shimizu T, Teshima Y, Higashi Y, Shimizu N, Saito M. Brain carbon monoxide can be involved in brain α7 nicotinic acetylcholine receptor-mediated suppression of the rat micturition reflex. Continence 2025 15S: 102123. doi.org/10.1016/j.cont.2025.102123
Hamada C, Shimizu T, Higashi Y, Shimizu N, Furumiya J, Saito M. Stimulation of brain thromboxane A2 receptors facilitates the micturition reflex through brain glutamatergic AMPA receptors in rats. Continence 2025 15S: 102218. doi.org/10.1016/j.cont.2025.102218
Sekido N, Omae K, Mitsui T, Haga N, Kubota Y, Saito M, Sakakibara R, Yoshida M, Masumori N, Takahashi S. Factors associated with co-existent overactive-underactive bladder: From the 2023 Japan Community Health Survey (JaCS 2023). Continence 2025 15S: 102016. doi.org/10.1016/j.cont.2025.102016
国際学会
International Continence Society and Emirates Urological Society, 55th Annual Meeting 会期: 9.18-20.2025 於: Abu Dhabi National Exhibition Centre (Abu Dhabi, UAE)Scientific Podium Short Oral Session
Shimizu T, Shimizu N, Tsubouchi S, Togo M, Higashi Y, Saito M: Centrally administered prostaglandin E2 suppresses the rat micturition reflex via brain EP1 and EP2 receptors.
Shimizu T, Takeuchi Y, Higashi Y, Shimizu N, Saito M. Centrally administered histamine facilitates the micturition reflex via brain H1 and H2 receptors in rats.
Shimizu T, Teshima Y, Higashi Y, Shimizu N, Saito M. Brain carbon monoxide can be involved in brain α7 nicotinic acetylcholine receptor-mediated suppression of the rat micturition reflex.
Hamada C, Shimizu T, Higashi Y, Shimizu N, Furumiya J, Saito M. Stimulation of brain thromboxane A2 receptors facilitates the micturition reflex through brain glutamatergic AMPA receptors in rats.
Sekido N, Omae K, Mitsui T, Haga N, Kubota Y, Saito M, Sakakibara R, Yoshida M, Masumori N, Takahashi S. Factors associated with co-existent overactive-underactive bladder: From the 2023 Japan Community Health Survey (JaCS 2023).
American Urological Association, 120th Annual Meeting 会期: 4.26-29.2025 於: The Venetian Convention & Expo Center (Las Vegas, NV, USA)
Podium session
Shimizu N, Shimizu T, Inoue K, Saito M. Brain nitric oxide inhibits the brain α7 nicotinic acetylcholine receptor-mediated suppression of the rat micturition reflex.
国内学会
第35回日本性機能学会学術総会・第35回日本性機能中部総会 会期:9.19-21.2025 於なんばスカイコンベンションホール（大阪府）座長
齊藤源顕：シンポジウム2：性機能研究の未来を拓く：若手研究者の挑戦
一般演題（口演）
吉村理愛、清水信貴、藏野吉隆、齊藤源顕、井上啓史：陰圧勃起補助器具「ビガー2020」の使用により勃起機能の改善を認めた脊髄損傷患者の一例
第32回日本排尿機能学会 会期:9.4-6.2025 於:SAGAアリーナ（佐賀県）
座長
齊藤源顕：謎と鍵企画１：排尿障害の基礎研究
齊藤源顕：イブニングセミナー１：基礎と臨床から過活動膀胱を考える
シンポジウム
東郷未緒、清水孝洋、東洋一郎、齊藤源顕：謎と鍵企画1、排尿障害の基礎研究：若手研究者として歩み始めた排尿障害研究
清水孝洋、清水信貴、藏野吉隆、東郷未緒、東洋一郎、齊藤源顕：謎と鍵企画3、排尿機能と性機能の関連：基礎研究から分かったこと
一般演題（口演）
濱田知里、清水孝洋、東郷未緒、東洋一郎、清水信貴、古宮淳一、齊藤源顕：排尿機能制御における脳内トロンボキサンA₂の役割
清水孝洋、武内結生、東郷未緒、東洋一郎、清水信貴、齊藤源顕：脳内ヒスタミンがラットの排尿機能におよぼす影響
清水孝洋、手嶋勇斗、東郷未緒、東洋一郎、清水信貴、齊藤源顕：脳内α7型ニコチン受容体刺激は脳内一酸化炭素を介して排尿を抑制する
東郷未緒、清水孝洋、東洋一郎、濱田知里、藏野吉隆、吉村理愛、清水信貴、齊藤源顕：雄性ラットを用いた筋原性低活動膀胱モデルの作成
吉村理愛、清水信貴、藏野吉隆、山本新九郎、水谷圭佑、辛島尚、齊藤源顕、井上啓史：女性の夜間頻尿に対するデスモプレシン使用症例の検討
第9回日本臨床薬理学会中国四国地方会 会期:8.30.2025 於:松江テルサ（島根県）
一般演題（ポスター）
清水孝洋、清水信貴、坪内駿、東郷未緒、東洋一郎、齊藤源顕：脳室内投与されたプロスタグランジンE2はラットの排尿を抑制する
第9回黒潮カンファレンス 会期:8.23-24.2025 於:休暇村大久野島（広島県）
座長
齊藤源顕：特別企画１：大久野島の毒ガス工場の歴史と課題
清水孝洋：若手研究者応援企画2：Rookiesセッション
一般演題（口演）
東郷未緒、清水孝洋、東洋一郎、齊藤源顕：雄性ラットを用いた筋原性低活動膀胱モデル動物作成の試み
一般演題（ポスター）
清水孝洋、清水信貴、坪内駿、東郷未緒、東洋一郎、齊藤源顕：ラット脳室内投与プロスタグランジンE2は排尿反射を抑制する
東洋一郎、谷大地、森下祐介、東郷未緒、清水孝洋、齊藤源顕：脳梗塞モデルマウスの機能障害と生存率へのオキシトシンの効果
第98回日本薬理学会年会 会期:3.17-19.2025 於:幕張メッセ（千葉県）
座長
齊藤源顕：「クスリがわかる」シリーズ講演「腎・泌尿器系」
シンポジウム
Saito M, Togo M, Higashi Y, Shimizu T: The necessity of the use of small animals in practices in medical students in the pharmacology class
一般演題（ポスター）
Shimizu T, Shimizu N, Inoue K, Saito M: Brain nitric oxide negatively regulates the brain α7 nicotinic acetylcholine receptor-mediated inhibition of the rat micturition reflex
Higashi Y, Morishita Y, Tani D, Togo M, Saito M: Intranasal oxytocin improves functional impairment in a mouse model of cerebral infarction
Takeuchi Y, Shimizu T, Saito M: Centrally administered histamine facilitates the rat micturition reflex
Teshima Y, Shimizu T, Saito M: Carbon monoxide is involved in α7 nicotinic acetylcholine receptor-mediated inhibition of the rat micturition reflex in the brain