My studies presently aim to answer : What are the structural proteins of the mitotic chromosome and how do they direct chromosome segregation in mitosis? Currently, we have identified 〜4,000 polypeptides in highly purified chicken mitotic chromosomes by using a mass-spectrometry based proteomic analysis. This seminar is going to focus on a novel approach that we term Multi-Classifier Combinatorial Proteomics, to sort through this massive proteomic data set and integrate multiple classifiers by machine learning uncovered functional relationships between protein complexes in the context of intact chromosomes.