高知大学医学部遺伝子機能解析学教室

Kawauchi, J., Inoue, M., Fukuda, M., Uchida, Y., Yasukawa, T., Conaway, R.C., Conaway, J.W., Aso, T., and Kitajima, S. Transcriptional properties of mammalian Elongin A and its role in stress response.
J. Biol. Chem. 288, 24302-24315, 2013.

Yasukawa, T., Bhatt, S., Takeuchi, T., Kawauchi, J., Takahashi, H., Tsutsui, A., Muraoka, T., Inoue, M., Tsuda, M., Kitajima, S., Conaway, R.C., Conaway, J.W., Trainor, P.A., and Aso, T. Transcriptional elongation factor Elongin A regulates retinoic acid-induced gene expression during neuronal differentiation.
Cell Rep. 2, 1129-1136, 2012.

Yamada, K., Tamamori-Adachi, M., Goto, I., Iizuka, M., Yasukawa, T., Aso, T., Okazaki, T., and Kitajima, S. Degradation of p21Cip1 through APC/CCdc20 mediated ubiquitylation is inhibited by cyclin dependent kinase 2 in cardiomyocytes.
J. Biol. Chem. 286, 44057-44066, 2011.

Yasukawa, T., Kamura, T., Kitajima, S., Conaway, R.C., Conaway, J.W., and Aso, T. Mammalian Elongin A complex mediates DNA-damage-induced ubiquitylation and degradation of Rpb1.
EMBO J. 27, 3256-3266, 2008. (Faculty of 1000 Biology)

Miyata, K.¶, Yasukawa, T.¶, Fukuda, M., Takeuchi, T., Yamazaki, K., Sakumi, K., Tamamori-Adachi, M., Ohnishi, Y., Ohtsuki, Y., Nakabeppu, Y., Kitajima, S., Onishi, S., and Aso, T. Induction of apoptosis and cellular senescence in mice lacking transcription elongation factor, Elongin A.
Cell Death Differ. 14, 716-726, 2007. (¶ equal contribution)

Yasukawa, T., Sugimura, K., Fukuda, M., Yamazaki, K., Kitajima, S., Okumura, K., and Aso, T. Functional characterization of a mammalian transcription factor, Elongin A.
Biochem. Biophys. Res. Commun. 352, 237-243, 2007.

Kinoshita, K., Goryo, K., Takada, M., Tomokuni, Y, Aso, T., Okuda, H., Shuin, T., Fukumura, H., and Sogawa, K. Ternary complex formation of pVHL, elongin B and elongin C visualized in living cells by a FRET-FLIM technique.
FEBS J., 274, 5567-5575, 2007.

Sugita H, Fujimoto M, Yasukawa T, Shimizu N, Sugita M, Yasuhara S, Martyn JA, Kaneki M.
Inducible nitric-oxide synthase and NO donor induce insulin receptor substrate-1 degradation in skeletal muscle cells.
J. Biol. Chem. 280, 14203-14211, 2005.

Sugita H, Kaneki M, Sugita M, Yasukawa T, Yasuhara S, Martyn JA.
Burn injury impairs insulin-stimulated Akt/PKB activation in skeletal muscle.
Am. J. Physiol. Endocrinol. Metab. 288, E585-591, 2005.

Yasukawa T, Tokunaga E, Ota H, Sugita H, Martyn JA, Kaneki M.
S-Nitrosylation-dependent inactivation of Akt/PKB in insulin resistance.
J. Biol. Chem. 280, 7511-7518, 2005.

Yasukawa T, Kaneki M, Yasuhara S, Lee SL, Martyn JA.
Steroidal non-depolarizing muscle relaxants do not simulate the effects of glucocorticoids on glucocorticoid receptor-mediated transcription in cultured skeletal muscle cells.
Anesthesiology. 100, 1615-1619, 2004.

Yamazaki, K., Aso, T., Ohnishi, Y., Ohno, M., Tamura, K., Shuin, T., Kitajima, S., and Nakabeppu, Y. Mammalian Elongin A is not essential for cell viability but is required for proper cell-cycle progression with limited alteration of gene expression.
J. Biol. Chem. 278, 13585-13589, 2003.

Tamura, K., Miyata, K., Sugahara, K., Onishi, S., Shuin, T., and Aso, T.
Identification of EloA-BP1, a novel Elongin A binding protein with an exonuclease homology domain.
Biochem. Biophys. Res. Commun. 276, 189-195, 2003.

Yamazaki, K., Guo, L., Sugahara, K., Zhang, C., Enzan, H., Nakabeppu, Y., Kitajima, S., and Aso, T. Identification and biochemical characterization of a novel transcription elongation factor, Elongin A3.
J. Biol. Chem. 277, 26444-26451, 2002.

Zhang, C., Yong, C., Adachi, M.T., Oshiro, S., Aso, T., Kaufman, R.J., and Kitajima, S. Homocysteine induces programmed cell death in human vascular endothelial cells through activation of the unfolded protein response.
J. Biol. Chem. 276, 35867-35874, 2001.

Zhang, C., Kawauchi, J., Adachi, M.T., Hashimoto, Y., Oshiro, S., Aso, T., and Kitajima, S. c-Jun NH2-terminal kinase and transcriptional repressor ATF3/LRF-1 is activated through endoplasmic reticulum stress and implicated in human vascular endothelial cell death by homocysteine.
Biochem. Biophys. Res. Commun. 289, 718-724, 2001.

Matsuda S, Yasukawa T, Homma Y, Shao Z, Ito Y, Niikura T, Hiraki T, Hirai S, Ohno S, Kita Y, Kawasumi M, Kouyama K, Yamamoto T, Kyriakis JM, Nishimoto I. c-Jun N-terminal kinase (JNK)-interacting protein-1b/islet-brain-1 scaffolds Alzheimer's amyloid precursor protein with JNK. J. Neurosci. 21, 6597-6607, 2001.

Hashimoto Y, Niikura T, Tajima H, Yasukawa T, Sudo H, Ito Y, Kita Y, Kawasumi M, Kouyama K, Doyu M, Sobue G, Koide T, Tsuji S, Lang J, Kurokawa K, Nishimoto I. A rescue factor abolishing neuronal cell death by a wide spectrum of familial Alzheimer's disease genes and Ab.
Proc. Natl. Acad. Sci. U.S.A. 98, 6336-6341, 2001.

Sudo H, Hashimoto Y, Niikura T, Shao Z, Yasukawa T, Ito Y, Yamada M, Hata M, Hiraki T, Kawasumi M, Kouyama K, and Nishimoto I.
Secreted Ab does not mediate neurotoxicity by antibody-stimulated amyloid precursor protein.
Biochem. Biophys. Res. Commun. 282, 548-556, 2001.

Niikura T, Hashimoto Y, Okamoto T, Abe Y, Yasukawa T, Kawasumi M, Hiraki T, Kita Y, Terashita K, Kouyama K and Nishimoto I. IGF-I protects cells from apoptosis by Alzheimer's V642I mutant APP through IGF-I receptor in an IGF binding protein-sensitive manner.
J. Neurosci. 21, 1902-1910, 2001

Kokura K, Kaul SC, Wadhwa R, Nomura T, Khan MM, Shinagawa T, Yasukawa T, Colmanares C, Ishii S. The Ski protein family is required for MeCP2-mediated transcriptional repression.
J. Biol. Chem. 276, 34115-34121, 2001.

Aso, T., Yamazaki, K., Amimoto, K., Kuroiwa, A., Higashi, H., Matsuda, Y., Kitajima, S., and Hatakeyama, M. Identification and characterization of Elongin A2, a new member of an Elongin family of transcription elongation factors, specifically expressed in the testis.
J. Biol. Chem. 275, 6546-6552, 2000.

Aso, T., Yamazaki, K., Aigaki, T., and Kitajima, S.
Drosophila von Hippel-Lindau tumor suppressor complex possesses E3 ubiquitin ligase activity.
Biochem. Biophys. Res. Commun. 276, 355-361, 2000.

Cai, Y., Zhang, C., Nawa, T., Aso, T., Tanaka, M., Oshiro, S., Ichijo, H., and Kitajima, S. Homocysteine-responsive ATF3 gene expression in human vascular endothelial cells: signal transduction pathway and promoter responsive element.
Blood 96, 2140-2148, 2000.

Sudo H¶, Jiang H¶, Yasukawa T¶, Hashimoto Y, Niikura T, Kawasumi M, Matsuda S, Takeuchi Y, Aiso S, Matsuoka M, Murayama Y and Nishimoto I.
Antibody regulated neurotoxic function of cell surface b-amyloid precursor protein.
Mol. Cell. Neurosci. 16, 708-723, 2000. (¶ equal contribution)

Ohh, M., Takagi, Y., Aso, T., Stebbins, C.E., Pavletich, N.P., Zbar, B., Conaway, R.C., Conaway, J.W., and Kaelin, W.G. Synthetic peptides define critical contacts between elongin C, elongin B, and the von Hippel-Lindau tumor suppressor protein.
J. Clin. Invest. 104, 1583-1591, 1999.

Aso, T., Amimoto, K., Takebayashi, K., Okumura, K., and Hatakeyama, M.
Structural organization and chromosome location of the mouse Elongin A gene (Tceb3).
Cytogenet. Cell Genet. 86, 259-262, 1999.

Shinobu, N., Maeda, T., Aso, T., Ito, T., Kondo, T., Koike, K., and Hatakeyama, M.
Physical interaction and functional antagonism between the RNA polymerase II elongation factor ELL and p53.
J. Biol. Chem. 274, 17003-17010, 1999.

Kittaka A, Kuze T, Amano M, Tanaka H, Miyasaka T, Hirose K, Yoshida T, Sarai A, Yasukawa T and Ishii S. Introduction of 6-formylcytidine into a Myb binding sequence.
Nucleosides Nucleotides. 18, 2769-2783, 1999.

Tokitou F, Nomura T, Khan MM, Kanl SC, Wadhwa K, Yasukawa T, Kohno I and Ishii S.
Viral ski inhibits retinoblastoma protein (Rb)-mediated transcriptional repression in a dominant negative fashon.
J. Biol. Chem. 274, 4485-4488, 1999.

Aso, T., and Conrad, M.N. Molecular cloning of DNAs encoding the regulatory subunits of Elongin from Saccharomyces cerevisiae and Drosophila melanogaster.
Biochem. Biophys. Res. Commun. 241, 334-340, 1997.

Pan, G., Aso, T., and Greenblatt, J.
Interaction of elongation factors TFIIS and elongin A with a human RNA polymerase II holoenzyme capable of promoter-specific initiation and responsive to transcriptional activators.
J. Biol. Chem. 272, 24563-24571, 1997.

Aso, T., Haque, D., Barstead, R.J., Conaway, R.C., and Conaway, J.W. The inducible elongin A elongation activation domain: structure, function and interaction with the elongin BC complex.
EMBO J. 15, 5557-5566, 1996.

Aso, T., Haque, D., Fukudome, K., Brower, C.S., Conaway, J.W. and Conaway, R.C.
A human cDNA encoding the 110-kDa A subunit of RNA polymerase II transcription factor elongin. Gene 168, 277-278, 1996.

Aso, T., Shilatifard, A., Conaway, J.W., and Conaway, R.C. Transcription syndromes and the role of RNA polymerase II general transcription factors in human disease.
J. Clin. Invest. 97, 1561-1569, 1996.

Kanei-Ishii C, Nomura T, Ogata K, Sarai A, Yasukawa T, Tashiro S, Takahashi T, Tanaka Y, Ishii S. Structure and function of the proteins encoded by the myb gene family.
Curr. Top. Microbiol. Immunol. 211, 89-98, 1996.

Dai P, Akimaru H, Tanaka T, Hou D-X, Yasukawa T, Kanei-Ishi C, Takahashi T and Ishii S.
CBP as a transcriptional coactivator of c-Myb.
Genes Dev. 10, 528-540, 1996.

Aso, T., Lane, W.S., Conaway, J.W., and Conaway, R.C.
Elongin (SIII): A multisubunit regulator of elongation by RNA polymerase II.
Science 269, 1439-1443, 1995.

Duan, D.R., Pause, A., Burgess, W.H., Aso, T., Chen, D.Y.T., Garrett, K.P., Conaway, R.C., Conaway, J.W., Linehan, W.M., and Klausner, R.D.
Inhibition of transcription elongation by the von Hippel-Lindau tumor suppressor protein.
Science 269, 1402-1406, 1995.

Garrett, K.P. ¶, Aso, T. ¶, Bradsher, J.N., Foundling, S.I., Lane, W.S., Conaway, R.C., and Conaway, J.W. Positive regulation of general transcription factor SIII by a tailed ubiquitin homolog.
Proc. Natl. Acad. Sci. U.S.A. 92, 7172-7176, 1995. (¶ equal contribution)

Aso, T., Makady, N., Haque, D., Conaway, R.C., and Conaway, J.W.
Assignment of a human gene encoding the 110-kDa subunit of general transcription factor elongin (SIII) to chromosome 1p36.1.
Genomics 30, 393-394, 1995.

Aso, T., Conaway, J.W., and Conaway, R.C. The RNA polymerase II elongation complex.
FASEB J. 9, 1419-1428, 1995.

Mizuguchi G, Kanei-Ishii C,Takahashi T, Yasukawa T, Nagase T, Horikoshi M, Yamamoto T and Ishii S. c-Myb Repression of c-erbB-2 Transcription by Direct Binding to the c-erbB-2 Promoter.
J. Biol. Chem. 270, 9384-9389, 1995.

Yasukawa T, Kanei-Ishii C, Maekawa T, Fujimoto J, Yamamoto T and Ishii S. Increase of Solubility of Foreign proteins in Eschericha coli by coproduction of the bacterial thioredoxin.
J. Biol. Chem. 270, 25328-25331, 1995.

Aso, T., Serizawa, H., Conaway, R.C., and Conaway, J.W. A TATA sequence-dependent transcriptional repressor activity associated with mammalian transcription factor IIA.
EMBO J. 13, 435-445, 1994.

Aso, T., Conaway, J.W., and Conaway, R.C.
Role of core promoter structure in assembly of the RNA polymerase II preinitiation complex.
J. Biol. Chem. 269, 26575-26583, 1994.

Tan, S, Aso, T., Conaway, R.C., and Conaway, J.W. Roles of both the RAP30 and RAP74 subunits of transcription factor IIF in transcription initiation and elongation by RNA polymerase II.
J. Biol. Chem. 269, 25684-25691, 1994.

Kanei-Ishii C, Yasukawa T, Morimoto RI and Ishii S. c-Myb-induced trans activation mediated by heat shock elements without sequence-specific DNA binding of c-Myb.
J. Biol. Chem. 269, 15768-15775, 1994.

Yonaha, M., Aso, T., Kobayashi, Y., Vasavada, H., Yasukochi, Y., Weissman, S.M., and Kitajima, S. Domain structure of a human general transcription initiation factor, TFIIF.
Nucleic Acid Res. 21, 273-279, 1993.

Aso, T., Tsai, P., Kawaguchi, T., Menninger, J.C., Kitajima, S., Yasukochi, Y., Ward, D.C., and Weissman, S.M. Assignment of the human GTF2F1 gene to chromosome 19p13.3.
Genomics 16, 252-253, 1993.

Sarai A, Uedaira H, Morii H, Yasukawa T, Ogata K, Nishimura Y and Ishii S.
Thermal stability of the DNA-binding domain of the Myb oncoprotein.
Biochemistry 39, 7759-7764, 1993.

Tanikawa J, Yasukawa T, Enari M, Ogata K, Nishimura Y, Ishii S and Sarai A.
Recognition of specific DNA sequences by the c-myb protooncogene product : Role of three repeat units in the DNA-binding domain.
Proc. Natl. Acad. Sci. U.S.A. 90, 9320-9324, 1993.

Aso, T., Vasavada, H., Kawaguchi, T., Germino, F.J., Ganguly, S., Kitajima, S., Weissman, S.M., and Yasukochi, Y.
Characterization of cDNA for the large subunit of the transcription initiation factor TFIIF.
Nature 355, 461-464, 1992.

Aso, T., Okamura, S., Matsuguchi, T., Sakamoto, N., Sata, T., and Niho, Y.
Genomic organization of the ?-chain of the human C4b-binding protein gene.
Biochem. Biophys. Res. Commun. 174, 222-227, 1991.

Matsuguchi, T., Okamura, S., Aso, T., Takahashi, K., and Niho, Y. Interleukin-6 and tumor necrosis factor alpha fully activate liver-specific gene expression of C4b-binding protein.
Biochem. Int. 23, 979-985, 1991.

Matsuguchi, T., Okamura, S., Aso, T., Sata, T., and Niho, Y. Molecular cloning of the cDNA coding for proline-rich protein (PRP): identity of PRP as C4b-binding protein.
Biochem. Biophys. Res. Commun. 165, 138-144, 1989.