◆Research findings by a group led by Professor Hiroaki Kitaoka of the Medical School of Medical School and Cardiovascular Medicine at Medical School have been published in *The New England Journal of Medicine*, an international academic journal published by the Massachusetts Medical Society.

Release Date:

Evaluation of the Efficacy of Mamakumten for Non-obstructive Hypertrophic Cardiomyopathy

　Research findings by a group led by Professor Hiroaki Kitaoka of Medical School of Medical School and Cardiovascular Medicine Medical School have been published in *The New England Journal of Medicine*, an international academic journal published by the Massachusetts Medical Society.

　Hypertrophic cardiomyopathy is a form of cardiomyopathy characterized by cardiac hypertrophy primarily caused by sarcomere gene mutations. It is broadly classified into obstructive hypertrophic cardiomyopathy, which involves obstruction, and non-obstructive hypertrophic cardiomyopathy, which does not involve obstruction; both can lead to sudden death and heart failure.Mabacumten is approved as a treatment for symptomatic obstructive hypertrophic cardiomyopathy in patients with heart failure symptoms. However, its efficacy for non-obstructive hypertrophic cardiomyopathy has not been established.

　Kochi University participated in the international Phase 3 clinical trial (the Odyssey-HCM trial) for this drug as the lead site in Japan, collaborating with leading institutions worldwide to evaluate its efficacy in treating non-obstructive hypertrophic cardiomyopathy.

　Although no statistically significant difference was observed, an improvement in patients’ subjective symptoms was noted. Additionally, improvements were observed in biomarkers used to assess cardiac workload. These findings demonstrate the efficacy of this drug in patients with hypertrophic cardiomyopathy.

[Press Release] Evaluation of the Efficacy of Mamakumten for Non-obstructive Hypertrophic Cardiomyopathy [PDF: 152 KB]

Mavacamten in Symptomatic Nonobstructive Hypertrophic Cardiomyopathy</p> <p><Translation> Mamakumten for Non-obstructive Hypertrophic Cardiomyopathy</p> <p>Paper URL:<a href="https://www.nejm.org/doi/full/10.1056/NEJMoa2505927"><span class="has-icon is-icon-external"> https://www.nejm.org/doi/full/10.1056/NEJMoa2505927</span></a></p> <footer class="kochi-post-footer"> <div class="kochi-post-footer-item"> <p>Category</p> <ul class="kochi-taxonomy-list is-type-category"> <li><a href="https://www.kochi-u.ac.jp/en/news/category/research/">Research</a></li> </ul> </div> <div class="kochi-post-footer-item"> <p>Share</p> <ul class="kochi-single-social-buttons"> <li><a class="kochi-single-social-button-facebook" href="https://www.facebook.com/sharer/sharer.php?u=https://www.kochi-u.ac.jp/news/2025101600018/" rel="nofollow" target="_blank">Share</a></li> <li><a class="kochi-single-social-button-x" href="https://x.com/intent/post?url=https%3A%2F%2Fwww.kochi-u.ac.jp%2Fnews%2F2025101600018%2F&title=%E2%97%86%E5%8C%BB%E5%AD%A6%E9%83%A8%E8%80%81%E5%B9%B4%E7%97%85%E3%83%BB%E5%BE%AA%E7%92%B0%E5%99%A8%E5%86%85%E7%A7%91%E5%AD%A6%E8%AC%9B%E5%BA%A7%20%E5%8C%97%E5%B2%A1%E8%A3%95%E7%AB%A0%E6%95%99%E6%8E%88%E3%82%89%E3%81%AE%E7%A0%94%E7%A9%B6%E3%82%B0%E3%83%AB%E3%83%BC%E3%83%97%E3%81%AE%E7%A0%94%E7%A9%B6%E6%88%90%E6%9E%9C%E3%81%8C%E3%80%81%E3%83%9E%E3%82%B5%E3%83%81%E3%83%A5%E3%83%BC%E3%82%BB%E3%83%83%E3%83%84%E5%86%85%E7%A7%91%E5%A4%96%E7%A7%91%E5%AD%A6%E4%BC%9A%E7%99%BA%E8%A1%8C%E3%81%AE%E5%9B%BD%E9%9A%9B%E5%AD%A6%E8%A1%93%E8%AA%8C%E3%80%8CThe%20New%20England%20Journal%20of%20Medicine%E3%80%8D%E3%81%AB%E6%8E%B2%E8%BC%89%E3%81%95%E3%82%8C%E3%81%BE%E3%81%97%E3%81%9F%E3%80%82%20%7C%20%E9%AB%98%E7%9F%A5%E5%A4%A7%E5%AD%A6&via=KochiU_News" rel="nofollow" target="_blank">Post</a></li> </ul> </div> <div class="wp-block-buttons is-horizontal is-content-justification-center is-layout-flex wp-block-buttons-is-layout-flex"> <div class="wp-block-button is-style-icon-internal"> <a class="wp-block-button__link wp-element-button is-medium-size" href="https://www.kochi-u.ac.jp/en/news/">Return to Announcements List</a> </div> </div> </footer> </div> <div class="c-scroll-top js-scroll-top is-hide"> <a href="#top">Return to top of page</a> </div> </main> <footer class="l-common-footer"> <div class="l-common-footer-container"> <div class="l-common-footer-inner"> <div class="c-footer-logos"> <div class="c-footer-logos-logo"><a href="https://www.kochi-u.ac.jp/en/"><svg aria-hidden="true" viewbox="0 0 191 42" xmlns="http://www.w3.org/2000/svg"><path d="m0 39.1 10.5-29 3.5-9.6h19.3l-.9 2.5c-4.9 2.1-10.1 5.2-14.4 10.5 0 0-9.6 10.8-1.7 20.2 0 0 1.1 1.5 3.7 3.2l-.8 2.3h-19.2" fill="#00a5e3"/><path d="m29.3 10.7c-6.2 5.7-5.6 10.5-5.6 10.7.4 3.8 2.9 6.4 7.2 7.6 3.2.9 6.2.7 6.3.7 12.5-.5 18.5-8.4 18.6-8.5 0 0 5.1-6.3 1-10.5-.1-.1-3.1-3.3-9.5-2.1 0 0-1.2.1-3.1 1.1 0 0-.1.1-.2.2v.2c.1.1 3.3 3.4.8 7.9-.6 1-1.7 2.1-3.1 3-4.1 2.3-9.1 1.8-10.7.9 0 0-1.8-.8-2.5-2.5-.7-1.6-.9-3.2.4-6.2 0 0 .8-2.2 2.8-3.9.1-.1.2-.2 0-.4s-.2-.1-.4 0c-.5.2-1.9 1.4-2.1 1.7z" fill="#00a5e3"/><path d="m69 10.8c-1.5-2.9-4.6-4.9-9.2-5.8 0 0-8.3-1.8-16.4 3.3-.1 0-.2.2 0 .4 0 .1.2.2.4.1 0 0 8.3-4.2 14.3 1.5 4.1 4.6-1 11.1-1 11.1s-6.4 8.6-19.8 9.3c-.1 0-13.5.7-14.5-9.3 0 0-1-6.5 9.5-14.2 0 0 7.2-5.7 16.4-6.1.2 0 .2-.1.2-.3s-.1-.2-.3-.2c0 0-4.5 0-10.3 1.6-5.4 1.5-13 4.7-19 11.7 0 .1-2.3 2.8-3.5 6.2-1.7 4.8-1 9.1 2.1 12.7 0 .1 2.3 2.7 7.2 4.7 4.5 1.8 12.2 3 23.6-.5 0 0 4-1.3 8.6-4 4.2-2.6 9.7-6.9 12.1-13.3 0-.2 2-4.7-.2-8.9z" fill="#004ea2"/><path d="m89.4 19.8v-1.5h7.1v1.5zm0 2.3h9.8v-6.1h-12.4v7.1h2.6zm10.9-15.6h-14.8v5.2h14.8zm4.4-3.6h-10.5v-2.4h-2.7v2.4h-10.5v2.5h23.7zm-20.2 12.1h16.9v6.9c0 .2 0 .3-.2.4-.1.1-.3.1-.5.1h-2.1c.3.7.5 1.2.6 1.5s.2.8.4 1.3l2.4-.3c.7-.1 1.3-.4 1.7-.8s.5-1 .5-1.8v-9.7h-22.5v12.7h2.8zm3.6-5.5v-1h9.7v1z"/><path d="m126.6 21.5h3.4v1.9h2.8v-19.3h-9.1v19.7h2.8v-2.3zm-13.8-2.4c-1 1.3-2.5 2.7-4.7 4.2.6.4 1.1.7 1.4 1s.6.7 1 1.2c1.6-1.2 2.9-2.3 3.7-3.3s1.6-2.3 2.4-4c.7 1.1 1.3 1.9 1.9 2.5s1.5 1.3 2.6 2.1c.4-.6.7-1 1-1.3.2-.3.7-.7 1.1-1.1-1.5-.8-2.6-1.6-3.4-2.4s-1.5-1.9-2.2-3.3v-.9h5.6v-2.5h-5.4v-4.7h4.2v-2.6h-7.6c.1-.4.2-.7.4-1 .1-.2.2-.6.4-1.1.2-.2.3-.4.4-.5 0-.1.1-.2.1-.4s0-.2 0-.2-.1-.1-.2-.1l-2.7-.8c-.4 1.7-1 3.2-1.7 4.7-.7 1.4-1.6 2.8-2.7 4.3.6.2 1.1.4 1.4.5.4.2.8.5 1.5.9.6-.9 1-1.6 1.3-2.1s.6-1 1-1.8h1.6v4.8h-6.7v2.5h6.5c-.4 2.1-1 3.8-2 5.2m13.6 0v-12.3h3.4v12.4h-3.4"/><path d="m148 9.7h-10.3v-2.7h10.5v-6.5h3v6.6h10.3v2.7h-10.3c.6 2.9 1.8 5.4 3.4 7.3 1.7 1.9 4.2 3.7 7.4 5.1-.7.7-1.3 1.1-1.4 1.3-.2.2-.5.5-.7 1-2.7-1.4-4.7-2.8-6.2-4.3-1.4-1.5-2.7-3.5-3.8-6-.8 2.6-2 4.6-3.5 6.2-1.6 1.6-3.7 3-6.6 4.3l-.6-.7c-.4-.5-.6-.8-.8-1s-.4-.4-.8-.7c2.2-.9 4-1.7 5.3-2.6s2.4-2 3.3-3.4c.6-.9 1-1.9 1.3-2.8s.5-2.2.7-3.7v-.2z"/><path d="m177 18.4h-10.8v-2.5h10.8v-2.7l1.6.3c.6-.4 1-.6 1.3-.8s.7-.5 1.2-.9h-10.1v-2.4h12.3l.8-.4 1.3 1.2c.2.2.3.3.4.4s.1.2.1.3 0 .2-.2.3c-.1.1-.3.2-.5.3-.9.7-1.7 1.3-2.4 1.8-.7.4-1.8 1.1-3.3 2v.5h10.9v2.5h-10.9v4.5c0 .7-.3 1.3-.8 1.6-.6.4-1.6.7-3 .8-.2-.5-.4-1-.6-1.3s-.4-.8-.8-1.4h1.9c.2 0 .4 0 .5-.2.1-.1.2-.2.2-.4v-3.7zm-7.3-6.3h-2.8v-6.6h13.8c.9-1.1 1.6-1.9 2.1-2.6.5-.6 1-1.5 1.7-2.4l2.6.7c.1 0 .2.1.4.2.1 0 .1.1.1.2s0 .2-.2.4c-.1.1-.4.3-.7.4-.5.6-.9 1.1-1.2 1.5s-.7.9-1.3 1.6h5.8v6.6h-2.8v-4.1h-17.5zm4.3-7.8-2.5 1.1c-.5-.9-.8-1.6-1.1-2s-.7-.9-1.2-1.6l2.4-1.1c.6.7 1 1.3 1.3 1.7s.7 1.1 1.2 1.9m5.8-.2-2.4.9c-.3-.8-.6-1.4-.8-1.9-.2-.4-.7-1.1-1.2-1.9l2.3-.9c.5.7.9 1.2 1.1 1.6s.6 1.1 1 2.1z"/><path d="m83.4 34.5 2.7-3.6h2.1l-3 3.7 3.3 4.6h-2.2l-2.8-4.2v4.2h-1.8v-8.3h1.8v3.6z"/><path d="m92.9 38.2c1 0 1.2-1 1.2-1.9s-.2-1.9-1.2-1.9-1.2 1-1.2 1.9.2 1.9 1.2 1.9zm0 1.1c-1.9 0-3-1.2-3-3s1.1-3 3-3 3 1.2 3 3-1.1 3-3 3z"/><path d="m101.4 35.4c0-.5-.2-1-.8-1s-.7 1.4-.8 1.8c0 .5 0 2 .8 2s.8-.7.8-1.1h1.6c0 1.5-1 2.3-2.5 2.3s-2.5-1.5-2.5-3 .8-3 2.5-3 2.5.9 2.5 2.2h-1.7z"/><path d="m105.2 39.1v-8.3h1.7v3.2c.4-.5.9-.9 1.8-.9s1.7.4 1.9 1.3c.1.4.1.7.1.9v3.7h-1.7v-3.5c0-.6-.2-1.3-1-1.3s-1 .5-1 1.3v3.5h-1.7z"/><path d="m115.1 30.9v1.5h-1.8v-1.5zm-.1 2.5v5.7h-1.7v-5.7z"/><path d="m128.3 30.9v5.2c0 2.2-1.6 3.3-3.6 3.3s-3.6-1-3.6-3.3v-5.2h1.8v4.5c0 1.4 0 2.7 1.8 2.7s1.8-1.3 1.8-2.7v-4.5z"/><path d="m132.6 34c.4-.5.9-.9 1.8-.9s1.7.4 1.9 1.3c.1.4.1.7.1.9v3.7h-1.7v-3.5c0-.6-.2-1.3-1-1.3s-1 .5-1 1.3v3.5h-1.7v-5.7h1.7v.7z"/><path d="m141.2 30.9v1.5h-1.8v-1.5zm0 2.5v5.7h-1.7v-5.7z"/><path d="m143.7 33.4h1.8l1.3 3.9 1.3-3.9h1.6l-2.1 5.8h-1.8z"/><path d="m155.1 35.5c0-.6-.2-1.2-1-1.2s-1 .6-1 1.2zm-2 1.2c0 .7.1 1.5 1 1.5s.9-.2 1-.7h1.5c-.1 1.4-1.3 1.9-2.6 1.9-1.9 0-2.7-1.1-2.7-3s1-3 2.7-3 1.9.4 2.4 1.4c.2.3.2.7.3 1v1.1h-3.7"/><path d="m161.3 33.4v1c.4-.9 1.1-1.2 1.9-1.1v1.5h-.7c-.3 0-.7.2-.8.4-.2.3-.2.7-.2 1v2.9h-1.7v-4.6c0-.2 0-.7 0-1.2h1.6z"/><path d="m168.6 34.9c0-.4-.4-.5-.8-.5s-.7.1-.7.5c0 .9 3.3.4 3.3 2.6s-1.5 1.9-2.6 1.9-2.5-.5-2.5-1.8h1.6c0 .4.4.7.9.7s.8-.2.8-.7-.8-.7-1.1-.7c-1.1-.2-2.1-.5-2.1-1.8s1.4-1.7 2.4-1.7 2.2.4 2.3 1.7h-1.5z"/><path d="m174.9 30.9v1.5h-1.8v-1.5zm0 2.5v5.7h-1.7v-5.7z"/><path d="m178.5 33.4v-1.2l1.7-.6v1.8h1.3v1.2h-1.3v2.7c0 .7.1 1 .7 1h.5v1c-.2.1-1.1.2-1.3.2-1.3 0-1.6-.7-1.6-1.9v-2.8h-1.1v-1.2h1.1z"/><path d="m188.3 33.4h1.7l-2.9 8h-1.7l.7-2.2-2.2-5.8h1.8l1.3 4z"/></svg><span class="screen-reader-text">Kochi University</span></a></div> <p class="c-footer-logos-description"> Super Regional University<br>Becoming a university that can support and transform the region. </p> </div> <div class="c-general-sns c-footer-sns"><ul><li class="menu-item menu-item-type-custom menu-item-object-custom menu-item-197"><a target="_blank" href="https://www.instagram.com/kochi_univ_official/">Instagram</a></li> <li class="menu-item menu-item-type-custom menu-item-object-custom menu-item-198"><a target="_blank" href="https://www.facebook.com/kochiuniversity/">Facebook</a></li> <li class="menu-item menu-item-type-custom menu-item-object-custom menu-item-199"><a target="_blank" href="https://x.com/KochiU_News">X</a></li> <li class="menu-item menu-item-type-custom menu-item-object-custom menu-item-200"><a target="_blank" href="https://www.youtube.com/user/kochidai">YouTube</a></li> <li class="menu-item menu-item-type-custom menu-item-object-custom menu-item-201"><a target="_blank" href="https://page.line.me/oqv6696m?openQrModal=true">LINE</a></li> </ul></div><div class="c-footer-primary"><ul><li><a class="c-button-icon is-bordered is-internal" href="https://www.kochi-u.ac.jp/en/prospective/">Prospective Students</a></li> <li><a class="c-button-icon is-bordered is-internal" href="https://www.kochi-u.ac.jp/en/current/">Current Students</a></li> <li><a class="c-button-icon is-bordered is-internal" href="https://www.kochi-u.ac.jp/en/graduates/">Alumni</a></li> <li><a class="c-button-icon is-bordered is-internal" href="https://www.kochi-u.ac.jp/en/business-and-public/">Business & Public</a></li> </ul></div><div class="c-footer-secondary"><ul><li><a class="c-button-icon is-internal" href="https://www.kochi-u.ac.jp/en/about/">About us</a></li> <li><a class="c-button-icon is-internal" href="https://www.kochi-u.ac.jp/en/academics/">Academics</a></li> <li><a class="c-button-icon is-internal" href="https://www.kochi-u.ac.jp/en/admissions/">Admissions Information</a></li> <li><a class="c-button-icon is-internal" href="https://www.kochi-u.ac.jp/en/education-support/">Education and Student Support</a></li> <li><a class="c-button-icon is-internal" href="https://www.kochi-u.ac.jp/en/research-collaboration/">Research and Community Collaboration</a></li> <li><a class="c-button-icon is-internal" href="https://www.kochi-u.ac.jp/en/global/">International Exchange</a></li> </ul></div><div class="c-footer-campuses"><dl><div class="c-footer-campuses-item"><dt>Asakura Campus</dt><dd><span class="c-footer-campuses-zip">〒780-8520 </span><span class="c-footer-campuses-address"> 5-1 Akebono-cho 2-chome, Kochi City, Kochi Prefecture</span><span class="c-footer-campuses-tel"> TEL 088-844-0111 (Main)</span></dd></div><div class="c-footer-campuses-item"><dt>Oko Campus</dt><dd><span class="c-footer-campuses-zip">783-8505 </span><span class="c-footer-campuses-address"> Kohasu, Okou-cho, Nankoku-shi, Kochi 783-8505, JAPAN </span><span class="c-footer-campuses-tel"> TEL 088-866-5811 (Main)</span></dd></div><div class="c-footer-campuses-item"><dt>Monobe Campus</dt><dd><span class="c-footer-campuses-zip">〒783-8502 </span><span class="c-footer-campuses-address"> 200 Monobe-otsu, Nankoku-shi, Kochi 783-8502, JAPAN</span><span class="c-footer-campuses-tel"> TEL 088-864-5114</span></dd></div></dl></div><div class="c-footer-misc"><ul><li class="menu-item menu-item-type-post_type menu-item-object-page menu-item-203"><a href="https://www.kochi-u.ac.jp/en/access/">Access</a></li> <li class="menu-item menu-item-type-post_type menu-item-object-page menu-item-204"><a href="https://www.kochi-u.ac.jp/en/about/recruitment/">Job Openings</a></li> <li class="menu-item menu-item-type-post_type menu-item-object-page menu-item-205"><a href="https://www.kochi-u.ac.jp/en/contact/">Contact</a></li> <li class="menu-item menu-item-type-post_type menu-item-object-page menu-item-206"><a href="https://www.kochi-u.ac.jp/en/site-policy/">Site Policy</a></li> <li class="menu-item menu-item-type-post_type menu-item-object-page menu-item-privacy-policy menu-item-207"><a rel="privacy-policy" href="https://www.kochi-u.ac.jp/en/privacy-policy/">Privacy Policy</a></li> <li class="menu-item menu-item-type-post_type menu-item-object-page menu-item-208"><a href="https://www.kochi-u.ac.jp/en/sitemap/">Sitemap</a></li> <li class="menu-item menu-item-type-post_type menu-item-object-page menu-item-209"><a href="https://www.kochi-u.ac.jp/en/internal/">For University Members Only</a></li> </ul></div> <p class="c-footer-copyright"><small>©Kochi University. All rights reserved.</small></p> </div> </div> </footer> <script type="speculationrules"> {"prefetch":[{"source":"document","where":{"and":[{"href_matches":"\/*"},{"not":{"href_matches":["\/wp-*.php","\/wp-admin\/*","\/wp-content\/uploads\/*","\/wp-content\/*","\/wp-content\/plugins\/*","\/wp-content\/themes\/kochi\/*","\/*\\?(.+)"]}},{"not":{"selector_matches":"a[rel~=\"nofollow\"]"}},{"not":{"selector_matches":".no-prefetch, .no-prefetch a"}}]},"eagerness":"conservative"}]} </script> <script src="https://www.kochi-u.ac.jp/wp-content/themes/kochi/assets/js/general.min.js?ver=1775035933" id="general-js"></script> </body> </html>