Report on the Association Between Lesions That Do Not Show Fluorescence with ALA-PDD and FGFR3 Expression
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Graduate SchoolDoctoral CourseMedicine ProgramResearch findings by Dr. Tatsu Shigehisa ( Medical School, Department of Urology) and colleagues were published in the academic journal *Photodiagnosis and Photodynamic Therapy*, with the online version released on April 22, Reiwa 8.
Photodynamic Diagnosis (PDD) enables accurate diagnosis by making cancer tissue fluoresce, thereby facilitating curative treatment. In the field of urology in Japan, this technology is being put into practical use, primarily through the efforts of our university; it has also been covered by health insurance and is becoming widespread nationwide. However, a challenge has been the presence of some “false-negative lesions”—lesions that do not fluoresce even when cancer is present.
A research group at Kochi University compared fluorescence-positive lesions with false-negative lesions from the same patient and performed immunohistochemical analysis of the expression of PEPT1, ABCG2, and FECH—molecules associated with ALA—as well as FGFR3, which has been suggested to be associated with bladder cancer characteristics.The results showed that while differences in the expression of PEPT1, ABCG2, and FECH alone could not fully explain the mechanism of false-negative results, FGFR3 expression varied among lesions in the false-negative group. This study is the first to investigate the possibility that FGFR3 expression differs between fluorescence-positive and -negative lesions within the same patient under ALA-PDD conditions.
In the future, it is expected that larger-scale molecular analyses will lead to improved accuracy in the prediction and diagnosis of cancers that are difficult to detect using PDD.
[Article Information]
Title: Discordant fibroblast growth factor receptor 3 (FGFR3) expression between photodynamic diagnosis-positive and -negative bladder cancer lesions: an intra-patient paired analysis
Authors: Ryu Shigehisa, Satoshi Fukata, Anantya Pustimbara, Chiaki Kawada, Rie Yoshimura, Erika Yamashita, Yoshitaka Kurano, Kaoru Furihata, Kaya Atagi, Daigo Takemori, Shinkuro Yamamoto, Hiroto Osakabe, Tomoya Nao, Hideo Fukuhara, Nobutaka Shimizu, Shingo Ashida, Atsushi Kurabayashi, Keiji Inoue
Journal: Photodiagnosis Photodyn Ther.
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